The Involvement of the Anterior Cingulate Cortex in Remote Contextual Fear Memory
Centre National de la Recherche Scientifique · University of Toronto · +4 more institutions
Abstract
Although the molecular, cellular, and systems mechanisms required for initial memory processing have been intensively investigated, those underlying permanent memory storage remain elusive. We present neuroanatomical, pharmacological, and genetic results demonstrating that the anterior cingulate cortex plays a critical role in remote memory for contextual fear conditioning. Imaging of activity-dependent genes shows that the anterior cingulate is activated by remote memory and that this activation is impaired by a null alpha-CaMKII mutation that blocks remote memory. Accordingly, reversible inactivation of this structure in normal mice disrupts remote memory without affecting recent memory.
Citation impact
- FWCI
- 11.14
- Percentile
- 100%
- References
- 31
Authors
5- PWPaul W. FranklandCorresponding
Centre National de la Recherche Scientifique, University of Toronto, Hospital for Sick Children, Laboratoire de Neurosciences Cognitives, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Institute of Neurobiology
- BBBruno BontempiCorresponding
Centre National de la Recherche Scientifique, University of Toronto, Hospital for Sick Children, Laboratoire de Neurosciences Cognitives, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Institute of Neurobiology
- LELynn E. Talton
Centre National de la Recherche Scientifique, University of Toronto, Hospital for Sick Children, Laboratoire de Neurosciences Cognitives, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Institute of Neurobiology
- LKLeszek Kaczmarek
Centre National de la Recherche Scientifique, University of Toronto, Hospital for Sick Children, Laboratoire de Neurosciences Cognitives, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Institute of Neurobiology
- AJAlcino J. SilvaCorresponding
Centre National de la Recherche Scientifique, University of Toronto, Hospital for Sick Children, Laboratoire de Neurosciences Cognitives, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Institute of Neurobiology
Topics & keywords
- Neuroscience
- Anterior cingulate cortex
- Cortex (anatomy)
- Psychology
- Memory formation
- Cognition
- Hippocampus
- Reduced inequalities