articleCancer ResearchDec 5, 2012Closed access

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

JBJonathan B. MitchemDJDonal J. BrennanBLBrett L. KnolhoffBABrian A. BeltYZYu Zhu

The University of Queensland · Pfizer (United States) · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in aggressive tumors. Consequently, the type and quality of immune responses present in the neoplastic stroma are highly predictive of patient outcome in several cancer types. In addition to host immune responses, intrinsic tumor cell activities that mimic stem cell properties have been linked to chemoresistance, metastatic dissemination, and the induction of immune suppression. Cancer stem cells are far from a static cell population; rather, their presence seems to be controlled by highly dynamic processes that are dependent on cues from the tumor stroma. However, the impact immune responses have on tumor stem cell…

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Topics & keywords

Topics
Keywords
  • Immunosuppression
  • Tumor cells
  • Cancer research
  • Medicine
  • Immunology
UN Sustainable Development Goals
  • Good health and well-being
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