Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
University of Iowa · National Institutes of Health · +3 more institutions
Abstract
Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. Our goals here were to test whether ascorbate killed cancer cells selectively, and if so, to determine mechanisms, using clinically relevant conditions. Cell death in 10 cancer and 4 normal cell types was measured by using 1-h exposures. Normal cells were unaffected by 20 mM ascorbate, whereas 5 cancer lines had EC(50) values of
Citation impact
- FWCI
- 18.06
- Percentile
- 100%
- References
- 64
Authors
8- QCQi ChenCorresponding
University of Iowa, National Institutes of Health, Center for Drug Evaluation and Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute
- MGMichael Graham Espey
University of Iowa, National Institutes of Health, Center for Drug Evaluation and Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute
- MCMurali C. Krishna
University of Iowa, National Institutes of Health, Center for Drug Evaluation and Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute
- JBJames B. Mitchell
University of Iowa, National Institutes of Health, Center for Drug Evaluation and Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute
- CCChristopher Corpe
University of Iowa, National Institutes of Health, Center for Drug Evaluation and Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute
Topics & keywords
- Ascorbic acid
- Programmed cell death
- Cancer cell
- Chemistry
- Hydrogen peroxide
- Apoptosis
- Necrosis
- Biochemistry
- Good health and well-being