Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data
Beth Israel Deaconess Medical Center · The George Institute for Global Health · +9 more institutions
Abstract
Hyperglycemia is associated with increased mortality in critically ill patients. Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality and increased rates of severe hypoglycemia. We conducted a meta-analysis to update the totality of evidence regarding the influence of intensive insulin therapy compared with conventional insulin therapy on mortality and severe hypoglycemia in the intensive care unit (ICU).
We conducted searches of electronic databases, abstracts from scientific conferences and bibliographies of relevant articles. We included published randomized controlled trials conducted in the ICU that directly compared intensive insulin therapy with conventional glucose management and that documented mortality. We included in our meta-analysis the data from the recent NICE-SUGAR (Normoglycemia in Intensive Care Evaluation - Survival Using Glucose Algorithm Regulation) study.
Citation impact
- FWCI
- 88.75
- Percentile
- 100%
- References
- 62
Authors
11- DGDonald GriesdaleCorresponding
Beth Israel Deaconess Medical Center, The George Institute for Global Health, Queen's University, McMaster University, Brigham and Women's Hospital, Kingston General Hospital, Harvard University, Royal North Shore Hospital, Vancouver General Hospital, University of British Columbia, The University of Sydney
- RJRussell J. de Souza
Vancouver General Hospital, The George Institute for Global Health, Beth Israel Deaconess Medical Center, The University of Sydney, McMaster University, Royal North Shore Hospital, Kingston General Hospital, Brigham and Women's Hospital, Harvard University, Queen's University
- RMRob M. van Dam
Royal North Shore Hospital, Harvard University, McMaster University, The George Institute for Global Health, Kingston General Hospital, The University of Sydney, Vancouver General Hospital, Queen's University, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital
- DKDaren K. Heyland
Royal North Shore Hospital, Queen's University, Kingston General Hospital, Beth Israel Deaconess Medical Center, McMaster University, Vancouver General Hospital, Harvard University, Brigham and Women's Hospital, The University of Sydney, The George Institute for Global Health
- DJD. J. Cook
The University of Sydney, Beth Israel Deaconess Medical Center, Queen's University, Brigham and Women's Hospital, McMaster University, Vancouver General Hospital, Royal North Shore Hospital, Kingston General Hospital, Harvard University, The George Institute for Global Health
Topics & keywords
- Medicine
- Hypoglycemia
- Intensive care unit
- Intensive care
- Relative risk
- Randomized controlled trial
- Insulin
- Intensive care medicine
- Good health and well-being