Autophagy Defends Cells Against Invading Group A Streptococcus
Japan Science and Technology Agency · Tokyo Metropolitan Institute of Medical Science · +2 more institutions
Abstract
We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.
Citation impact
- FWCI
- 26.19
- Percentile
- 100%
- References
- 20
Authors
12- INIchirô NakagawaCorresponding
Japan Science and Technology Agency, Tokyo Metropolitan Institute of Medical Science, The University of Osaka
- AAAtsuo Amano
Japan Science and Technology Agency, Tokyo Metropolitan Institute of Medical Science, The University of Osaka
- NMNoboru Mizushima
Japan Science and Technology Agency, Tokyo Metropolitan Institute of Medical Science, The University of Osaka
- AYAkitsugu Yamamoto
Nagahama Institute of Bio-Science and Technology, Japan Science and Technology Agency, Tokyo Metropolitan Institute of Medical Science, The University of Osaka
- HYHitomi Yamaguchi
Japan Science and Technology Agency, Tokyo Metropolitan Institute of Medical Science, The University of Osaka
Topics & keywords
- Autophagy
- Endosome
- Cell biology
- Cytoplasm
- ATG5
- Biology
- Phagosome
- Phagocytosis