In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer
Délégation Paris 5 · Austrian Academy of Sciences · +8 more institutions
Abstract
PURPOSE: Many patients who present with early-stage colorectal cancer (International Union Against Cancer TNM stages I and II) are nevertheless at high risk of relapse. We hypothesized that intratumoral immune reaction could influence their prognosis. PATIENTS AND METHODS: The intratumoral immune reaction was investigated in 29 tumors by large-scale real-time polymerase chain reaction. Cytotoxic (CD8) and memory (CD45RO) T cells were quantified by immunohistochemical analyses of tissue microarrays from the center (CT) and the invasive margin (IM) of the 602 tumors from two independent cohorts. The results were correlated with tumor recurrence and patient survival. RESULTS: Patients with a strong infiltration…
Citation impact
- FWCI
- 14.71
- Percentile
- 100%
- References
- 27
Authors
15- FPFranck Pagès
Délégation Paris 5, Austrian Academy of Sciences, Inserm, Medical University of Graz, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Ministry of Science, Fondation ARC pour la Recherche sur le Cancer
- AKAmos Kirilovsky
Délégation Paris 5, Austrian Academy of Sciences, Inserm, Medical University of Graz, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Ministry of Science, Fondation ARC pour la Recherche sur le Cancer
- BMBernhard Mlecnik
Délégation Paris 5, Austrian Academy of Sciences, Inserm, Medical University of Graz, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Ministry of Science, Fondation ARC pour la Recherche sur le Cancer
- MAMartin Asslaber
Délégation Paris 5, Austrian Academy of Sciences, Inserm, Medical University of Graz, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Ministry of Science, Fondation ARC pour la Recherche sur le Cancer
- MTMarie Tosolini
Délégation Paris 5, Austrian Academy of Sciences, Inserm, Medical University of Graz, Université Paris Cité, Sorbonne Université, Graz University of Technology, Centre de Recherche des Cordeliers, Ministry of Science, Fondation ARC pour la Recherche sur le Cancer
Topics & keywords
- Medicine
- Colorectal cancer
- Cytotoxic T cell
- CD8
- Immune system
- Stage (stratigraphy)
- Oncology
- Tissue microarray
- Good health and well-being