Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections
Centers for Disease Control and Prevention · National Center for Emerging and Zoonotic Infectious Diseases · +6 more institutions
Abstract
Salmonella enterica infections are common causes of bloodstream infection in low-resource areas, where they may be difficult to distinguish from other febrile illnesses and may be associated with a high case fatality ratio. Microbiologic culture of blood or bone marrow remains the mainstay of laboratory diagnosis. Antimicrobial resistance has emerged in Salmonella enterica, initially to the traditional first-line drugs chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole. Decreased fluoroquinolone susceptibility and then fluoroquinolone resistance have developed in association with chromosomal mutations in the quinolone resistance-determining region of genes encoding DNA gyrase and topoisomerase IV…
Citation impact
- FWCI
- 80.28
- Percentile
- 100%
- References
- 627
Authors
4- JAJohn A. CrumpCorresponding
Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, University of Otago
- MSMaria Sjölund-Karlsson
Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases
- MAMelita A. Gordon
University of Liverpool, Malawi-Liverpool-Wellcome Trust Clinical Research Programme
- CMChristopher M. Parry
Liverpool School of Tropical Medicine, London School of Hygiene & Tropical Medicine, Nagasaki University
Topics & keywords
- Salmonella enterica
- Salmonella
- Ciprofloxacin
- Microbiology
- Medicine
- DNA gyrase
- Antibiotic resistance
- Typhoid fever