Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
Brigham and Women's Hospital · Harvard University · +3 more institutions
Abstract
Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative contribution to atherogenesis remains unknown. We report here that the Ly-6C(hi) monocyte subset increased dramatically in hypercholesterolemic apoE-deficient mice consuming a high-fat diet, with the number of Ly-6C(hi) cells doubling in the blood every month. Ly-6C(hi) monocytes adhered to activated endothelium, infiltrated lesions, and became lesional macrophages. Hypercholesterolemia-associated monocytosis (HAM) developed from increased survival, continued cell proliferation, and impaired…
Citation impact
- FWCI
- 20.60
- Percentile
- 100%
- References
- 57
Authors
7- FKFilip K. ŚwirskiCorresponding
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Cardiovascular Research Center
- PLPeter Libby
Brigham and Women's Hospital, Harvard University, Cardiovascular Research Center
- EAElena Aïkawa
Harvard University, Massachusetts General Hospital
- PAPilar Alcaide
Brigham and Women's Hospital
- FWF W Luscinskas
Brigham and Women's Hospital
Topics & keywords
- Monocytosis
- Macrophage
- Monocyte
- Immunology
- Medicine
- Inflammation
- Leukocytosis
- Biology