From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent Learning
Universidad de Buenos Aires · Civitan International · +2 more institutions
Abstract
One of the most rigorously investigated problems in modern neuroscience is to decipher the mechanisms by which experience-induced changes in the central nervous system are translated into behavioral acquisition, consolidation, retention, and subsequent recall of information. Brain-derived neurotrophic factor (BDNF) has recently emerged as one of the most potent molecular mediators of not only central synaptic plasticity, but also behavioral interactions between an organism and its environment. Recent experimental evidence indicates that BDNF modulates synaptic transmission and plasticity by acting across different spatial and temporal domains. BDNF signaling evokes both short- and long-term periods of enhanced…
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- References
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Authors
4- WJWilliam J. TylerCorresponding
Universidad de Buenos Aires, Civitan International, University of Alabama at Birmingham, University of Bergen
- MAMariana Alonso
Universidad de Buenos Aires, Civitan International, University of Alabama at Birmingham, University of Bergen
- CRClive R. Bramham
Universidad de Buenos Aires, Civitan International, University of Alabama at Birmingham, University of Bergen
- LPLucas Pozzo‐Miller
Universidad de Buenos Aires, Civitan International, University of Alabama at Birmingham, University of Bergen
Topics & keywords
- Neuroscience
- Tropomyosin receptor kinase B
- Synaptic plasticity
- Neurotrophic factors
- Memory consolidation
- Hippocampal formation
- Brain-derived neurotrophic factor
- Metaplasticity