Estimating and interpreting F ST : The impact of rare variants
Broad Institute · Harvard–MIT Division of Health Sciences and Technology · +3 more institutions
Abstract
In a pair of seminal papers, Sewall Wright and Gustave Malécot introduced FST as a measure of structure in natural populations. In the decades that followed, a number of papers provided differing definitions, estimation methods, and interpretations beyond Wright's. While this diversity in methods has enabled many studies in genetics, it has also introduced confusion regarding how to estimate FST from available data. Considering this confusion, wide variation in published estimates of FST for pairs of HapMap populations is a cause for concern. These estimates changed-in some cases more than twofold-when comparing estimates from genotyping arrays to those from sequence data. Indeed, changes in FST from…
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Authors
4- GBGaurav BhatiaCorresponding
Broad Institute, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- NPNick Patterson
Broad Institute
- SSSriram Sankararaman
Broad Institute, Harvard University
- ALAlkes L. Price
Broad Institute, Massachusetts Department of Public Health, Harvard University
Topics & keywords
- Biology
- International HapMap Project
- Evolutionary biology
- Genetics
- Population
- Allele frequency
- Minor allele frequency
- Single-nucleotide polymorphism