CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus
Albany State University · New York State Department of Health · +6 more institutions
Abstract
Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus that causes severe acute respiratory syndrome [Li, W. Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454]. We have identified a different human cellular glycoprotein that can serve as an alternative receptor for SARS-CoV. A human lung cDNA library in vesicular stomatitis virus G pseudotyped retrovirus was transduced into Chinese hamster ovary cells, and the cells were sorted for binding of soluble SARS-CoV spike (S) glycoproteins, S(590) and S(1180). Clones of transduced cells that bound SARS-CoV S…
Citation impact
- FWCI
- 20.62
- Percentile
- 100%
- References
- 47
Authors
14- SAScott A. JeffersCorresponding
Albany State University, New York State Department of Health, Wadsworth Center, University of Massachusetts Chan Medical School, National Jewish Health, University at Albany, State University of New York, University of Colorado Health, University of Colorado Denver
- SMSonia M. TusellCorresponding
Albany State University, New York State Department of Health, Wadsworth Center, University of Massachusetts Chan Medical School, National Jewish Health, University at Albany, State University of New York, University of Colorado Health, University of Colorado Denver
- LGLaura Gillim-Ross
Albany State University, New York State Department of Health, Wadsworth Center, University of Massachusetts Chan Medical School, National Jewish Health, University at Albany, State University of New York, University of Colorado Health, University of Colorado Denver
- EMErin M. Hemmila
Albany State University, New York State Department of Health, Wadsworth Center, University of Massachusetts Chan Medical School, National Jewish Health, University at Albany, State University of New York, University of Colorado Health, University of Colorado Denver
- JEJenna E. Achenbach
Albany State University, New York State Department of Health, Wadsworth Center, University of Massachusetts Chan Medical School, National Jewish Health, University at Albany, State University of New York, University of Colorado Health, University of Colorado Denver
Topics & keywords
- Virology
- Biology
- Chinese hamster ovary cell
- Complementary DNA
- Molecular biology
- Coronavirus
- Vesicular stomatitis virus
- Transfection
- Good health and well-being