Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
Radboud University Nijmegen · Amsterdam UMC Location University of Amsterdam · +9 more institutions
Abstract
PURPOSE: To determine the prevalence and prognostic value of mismatch repair (MMR) status and its relation to BRAF mutation (BRAF(MT)) status in metastatic colorectal cancer (mCRC). EXPERIMENTAL DESIGN: A pooled analysis of four phase III studies in first-line treatment of mCRC (CAIRO, CAIRO2, COIN, and FOCUS) was performed. Primary outcome parameter was the hazard ratio (HR) for median progression-free survival (PFS) and overall survival (OS) in relation to MMR and BRAF. For the pooled analysis, Cox regression analysis was performed on individual patient data. RESULTS: The primary tumors of 3,063 patients were analyzed, of which 153 (5.0%) exhibited deficient MMR (dMMR) and 250 (8.2%) a BRAF(MT). BRAF(MT) was…
Citation impact
- FWCI
- 17.41
- Percentile
- 100%
- References
- 48
Authors
16- SVSabine Venderbosch
Radboud University Nijmegen, Amsterdam UMC Location University of Amsterdam, Radboud University Medical Center, University of Amsterdam
- IDIrıs D. Nagtegaal
Radboud University Nijmegen, Radboud University Medical Center
- TMTim Maughan
CRUK/MRC Oxford Institute for Radiation Oncology
- CGChristopher G. Smith
Cardiff University, Cardiff Metropolitan University
- JPJeremy P. Cheadle
Cardiff University, Cardiff Metropolitan University
Topics & keywords
- Medicine
- Internal medicine
- Hazard ratio
- Colorectal cancer
- Oncology
- Confidence interval
- Proportional hazards model
- DNA mismatch repair
- No poverty