Biomaterial based modulation of macrophage polarization: a review and suggested design principles
Trinity College Dublin · Royal College of Surgeons in Ireland
Abstract
<p>Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in recent years due to their ability to polarize into pro-inflammatory and anti-inflammatory phenotypes. Historically, biomaterials were designed to be inert to minimize the host response. More recently, the emergence of tissue engineering and regenerative medicine has led to the design of biomaterials that interact with the host through tailored mechanical, chemical and temporal characteristics. Due to such advances in biomaterial functionality and an improved understanding of macrophage responses to implanted materials, it is now possible to identify…
Citation impact
- FWCI
- 45.81
- Percentile
- 100%
- References
- 99
Authors
5- RSRukmani Sridharan
Trinity College Dublin, Royal College of Surgeons in Ireland
- ARAndrew R. Cameron
Trinity College Dublin, Royal College of Surgeons in Ireland
- DJDaniel J. Kelly
Royal College of Surgeons in Ireland, Trinity College Dublin
- CJCathal J. Kearney
Trinity College Dublin, Royal College of Surgeons in Ireland
- FJFergal J. O’BrienCorresponding
Trinity College Dublin, Royal College of Surgeons in Ireland
Topics & keywords
- Biomaterial
- Macrophage polarization
- Macrophage
- Regenerative medicine
- Immune system
- Nanotechnology
- Materials science
- Cell biology