Transcriptional Regulatory Elements in the Human Genome
Howard Hughes Medical Institute · University of Massachusetts Chan Medical School
Abstract
The faithful execution of biological processes requires a precise and carefully orchestrated set of steps that depend on the proper spatial and temporal expression of genes. Here we review the various classes of transcriptional regulatory elements (core promoters, proximal promoters, distal enhancers, silencers, insulators/boundary elements, and locus control regions) and the molecular machinery (general transcription factors, activators, and coactivators) that interacts with the regulatory elements to mediate precisely controlled patterns of gene expression. The biological importance of transcriptional regulation is highlighted by examples of how alterations in these transcriptional components can lead to…
Citation impact
- FWCI
- 13.22
- Percentile
- 100%
- References
- 203
Authors
3- GAGlenn A. MastonCorresponding
Howard Hughes Medical Institute, University of Massachusetts Chan Medical School
- SKSara K. Evans
Howard Hughes Medical Institute, University of Massachusetts Chan Medical School
- MRMichael R. Green
Howard Hughes Medical Institute, University of Massachusetts Chan Medical School
Topics & keywords
- Enhancer
- Promoter
- Computational biology
- Biology
- Transcriptional regulation
- Regulation of gene expression
- Regulatory sequence
- Gene