Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

Gusev, Alexander; Lee, Sang; Trynka, Gosia; Finucane, Hilary K.; Vilhjálmsson, Bjarni J.; Xu, Han; Zang, Chongzhi; Ripke, Stephan; Bulik‐Sullivan, Brendan; Stahl, Eli A.; Kähler, Anna K.; Hultman, Christina M.; Purcell, Shaun; McCarroll, Steven A.; Daly, Mark J.; Paşaniuc, Bogdan; Sullivan, Patrick F.; Neale, Benjamin M.; Wray, Naomi R.; Raychaudhuri, Soumya; Price, Alkes L.; Ripke, Stephan; Neale, Benjamin M.; Corvin, Aiden; Walters, James; Farh, Kai-How; Holmans, Peter; Lee, Phil; Bulik‐Sullivan, Brendan; Collier, David; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu‐Alin; Begemann, Martin; Belliveau, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Børglum, Anders D.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond; Chen, Ronald Y.L.; Chen, Eric; Cheng, Wei; Cheung, Eric; Chong, Siow Ann; Cloninger, C. Robert; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael H.; Davis, Kenneth L.; Degenhardt, Franziska; Del‐Favero, Jurgen; DeLisi, Lynn E.; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy G.; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan G.; Escott‐Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Gershon, Elliot S.; Giegling, Ina; Giusti-Rodrguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Голимбет, В. Е.; Gopal, Srihari; Gratten, Jacob; Grove, Jakob; Haan, Lieuwe de; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas Folkmann; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S.; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kelly, Brian; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Kloviņš, Jānis; Knowles, James A.; Konte, Bettina; Kučinskas, Vaidutis; Kučinskienė, Zita Aušrelė; Kuzelova-Ptackova, Hana; Kähler, Anna K.; Laurent, Claudine; Keong, Jimmy Lee Chee; Lee, Sang; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey A.; Sa, Limborskaia; Loughland, Carmel M.; Lubiński, Jan; Lnnqvist, Jouko; Maçek, Milan; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Béla; Melle, Ingrid; Mesholam‐Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Mortensen, Preben Bo; Murphy, Kieran C.; Murray, Robin; Myin‐Germeys, Inez; Mller-Myhsok, Bertram; Nelis, Mari; Nenadić, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Ņikitina-Zaķe, Liene; Nisenbaum, Laura; Nordin, Annelie; O’Callaghan, Eadbhard; O’Dushlaine, Colm; O’Neill, F. Anthony; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Os, Jim van; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejović-Milovančević, Milica; Perkins, Diana O.; Pietilinen, Olli; Pimm, Jonathan; Pocklington, Andrew; Powell, John; Price, Alkes L.; Pulver, Ann E.; Purcell, Shaun; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurðsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, P. A.; Smoller, Jordan W.; So, Hon‐Cheong; Spencer, Chris C. A.; Stahl, Eli A.; Stefánsson, Hreinn; Steinberg, Stacy; Stögmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Strohmaier, Jana; Stroup, T. Scott; Subramaniam, Mythily; Suvisaari, Jaana; Švrakić, Dragan M.; Szatkiewicz, Jin; Sderman, Erik; Thirumalai, Srinivas; Тончева, Драга; Tooney, Paul A.; Tosato, Sarah; Veijola, Juha; Waddington, John L.; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily; Wormley, Brandon K.; Wu, Jing; Xi, Hualin Simon; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R.; Stefánsson, Kāri; Visscher, Peter M.; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas; Bramon, Elvira; Buxbaum, Joseph D.; B�rglum, Anders D.; Cichon, Sven; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen; Jönsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben Bo; Mowry, Bryan; Nthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Daniëlle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; Clair, David St; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O‘Donovan, Michael; Ripke, Stephan; O’Dushlaine, Colm; Chambert, Kimberly; Moran, Jennifer L.; Kähler, Anna K.; Akterin, Susanne; Bergen, Sarah E.; Magnusson, Patrik K. E.; Neale, Benjamin M.; Ruderfer, Douglas M.; Scolnick, Edward M.; Purcell, Shaun; McCarroll, Steve; Sklar, Pamela; Hultman, Christina M.; Sullivan, Patrick F.

doi:10.1016/j.ajhg.2014.10.004

articleThe American Journal of Human GeneticsNov 1, 2014BRONZE OA

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

AGAlexander Gusev SLSang Lee GTGosia Trynka HKHilary K. Finucane BJBjarni J. Vilhjálmsson

Harvard University · The University of Queensland · +11 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

653

total citations

FWCI: 52.79
Percentile: 100%
References: 92

Citations per year

Authors

345

AG
Alexander GusevCorresponding
Harvard University
SL
Sang Lee
The University of Queensland
GT
Gosia Trynka
Broad Institute, Brigham and Women's Hospital, Harvard University, Mass General Brigham
HK
Hilary K. Finucane
Massachusetts Institute of Technology
BJ
Bjarni J. Vilhjálmsson
Harvard University

Topics & keywords

Topics

Genetic Associations and Epidemiology99%
Genomics and Rare Diseases98%
Celiac Disease Research and Management95%

Keywords

Heritability
Genetics
Biology
Computational biology
Type (biology)
Evolutionary biology
Ecology

No related works found for this paper.

Funding

WT
Wellcome Trust
MR
Medical Research Council
Award: MR/L010305/1