articlePLoS Computational BiologyApr 30, 2009GOLD OA

Functional Brain Networks Develop from a “Local to Distributed” Organization

Oregon Health & Science University · Washington University in St. Louis · +1 more institution

PubMed
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Abstract

The mature human brain is organized into a collection of specialized functional networks that flexibly interact to support various cognitive functions. Studies of development often attempt to identify the organizing principles that guide the maturation of these functional networks. In this report, we combine resting state functional connectivity MRI (rs-fcMRI), graph analysis, community detection, and spring-embedding visualization techniques to analyze four separate networks defined in earlier studies. As we have previously reported, we find, across development, a trend toward 'segregation' (a general decrease in correlation strength) between regions close in anatomical space and 'integration' (an increased…

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Authors

8

Topics & keywords

Keywords
  • Modularity (biology)
  • Clustering coefficient
  • Cognition
  • Connectome
  • Computer science
  • Graph theory
  • Connectomics
  • Betweenness centrality
UN Sustainable Development Goals
  • Quality Education
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