articleGenome ResearchNov 1, 2003BRONZE OA

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

Institute for Systems Biology · Whitehead Institute for Biomedical Research · +1 more institution

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Abstract

Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expression data and other molecular states into a unified conceptual framework. Although applicable to any system of molecular components and interactions, Cytoscape is most powerful when used in conjunction with large databases of protein-protein, protein-DNA, and genetic interactions that are increasingly available for humans and model organisms. Cytoscape's software Core provides basic functionality to layout and query the network; to visually integrate the network with expression profiles, phenotypes, and other molecular states; and to link the network to databases of functional annotations.…

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