Mendelian randomization of blood lipids for coronary heart disease

Holmes, Michael V.; Asselbergs, Folkert W.; Palmer, Tom; Drenos, Fotios; Lanktree, Matthew B.; Nelson, Christopher P.; Dale, Caroline; Padmanabhan, Sandosh; Finan, Chris; Swerdlow, Daniel I.; Tragante, Vinicius; Iperen, Erik P.A. van; Sivapalaratnam, Suthesh; Shah, Sonia; Elbers, Clara C.; Shah, Tina; Engmann, Jorgen; Giambartolomei, Claudia; White, Jon; Zabaneh, Delilah; Sofat, Reecha; McLachlan, Stela; Doevendans, Pieter A.; Balmforth, Anthony J.; Hall, Alistair S.; North, Kari E.; Almoguera, Berta; Hoogeveen, Ron C.; Cushman, Mary; Fornage, Myriam; Patel, Sanjay R.; Redline, Susan; Siscovick, David S.; Tsai, Michael Y.; Karczewski, Konrad J.; Hofker, Marten H.; Verschuren, W. M. Monique; Bots, Michiel L.; Schouw, Yvonne T. van der; Melander, Olle; Dominiczak, Anna F.; Morris, Richard; Ben‐Shlomo, Yoav; Price, Jackie F.; Kumari, Meena; Baumert, Jens; Peters, Annette; Thorand, Barbara; Köenig, Wolfgang; Gaunt, Tom R.; Humphries, Steve E.; Clarke, Robert; Watkins, Hugh; Farrall, Martin; Wilson, James G.; Rich, Stephen S.; Bakker, Paul I. W. de; Lange, Leslie A.; Smith, George Davey; Reiner, Alex P.; Talmud, Philippa J.; Kivimäki, Mika; Lawlor, Debbie A.; Dudbridge, Frank; Samani, Nilesh J.; Keating, Brendan J.; Hingorani, Aroon D.; Casas, Juan P.

doi:10.1093/eurheartj/eht571

reviewEuropean Heart JournalJan 28, 2014HYBRID OA

Mendelian randomization of blood lipids for coronary heart disease

MVMichael V. Holmes FWFolkert W. Asselbergs TPTom Palmer FDFotios Drenos MBMatthew B. Lanktree

University of Pennsylvania · University College London · +35 more institutions

PubMed

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Abstract

AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a prior meta-analysis (threshold P

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Topics & keywords

Topics

Keywords

Mendelian randomization
Single-nucleotide polymorphism
Medicine
Allele
Internal medicine
Cholesterol
Genetics
Gastroenterology

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Good health and well-being

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