Time Trends and Local Variation in Primary Treatment of Localized Prostate Cancer

PURPOSE In the absence of high-level evidence or clinical guidelines supporting any given active treatment approach over another for localized prostate cancer, clinician and patient preferences may lead to substantial variation in treatment use. METHODS Data were analyzed from 36 clinical sites that contributed data to the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) registry. Distribution of primary treatment use was measured over time. Prostate cancer risk was assessed using the D'Amico risk groups and the Cancer of the Prostate Risk Assessment (CAPRA) score. Descriptive analyses were performed, and a hierarchical model was constructed that controlled for year of diagnosis, cancer…

• AL
  Abbott Laboratories
• AS
  American Society of Clinical Oncology
• NI
  National Institutes of Health
• UO
  University of California, San Francisco
• NC
  National Cancer Institute