Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
Istituto Oncologico Veneto · Istituti di Ricovero e Cura a Carattere Scientifico · +8 more institutions
Abstract
Tumor-promoted constraints negatively affect cytotoxic T lymphocyte (CTL) trafficking to the tumor core and, as a result, inhibit tumor killing. The production of reactive nitrogen species (RNS) within the tumor microenvironment has been reported in mouse and human cancers. We describe a novel RNS-dependent posttranslational modification of chemokines that has a profound impact on leukocyte recruitment to mouse and human tumors. Intratumoral RNS production induces CCL2 chemokine nitration and hinders T cell infiltration, resulting in the trapping of tumor-specific T cells in the stroma that surrounds cancer cells. Preconditioning of the tumor microenvironment with novel drugs that inhibit CCL2 modification…
Citation impact
- FWCI
- 13.95
- Percentile
- 100%
- References
- 78
Authors
19- BMBarbara MolonCorresponding
Istituto Oncologico Veneto, Istituti di Ricovero e Cura a Carattere Scientifico
- SUStefano Ugel
Veneto Institute of Molecular Medicine, Istituto Oncologico Veneto, Istituti di Ricovero e Cura a Carattere Scientifico
- FDFederica Del Pozzo
IRCCS Humanitas Research Hospital
- CSCristiana Soldani
IRCCS Humanitas Research Hospital
- SZSerena Zilio
University of Padua
Topics & keywords
- Tumor microenvironment
- Chemokine
- Cancer research
- CTL*
- Cytotoxic T cell
- Cancer immunotherapy
- Immunotherapy
- Infiltration (HVAC)