Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse cellular processes. Determining the function of individual lincRNAs remains a challenge. Recent advances in RNA sequencing (RNA-seq) and computational methods allow for an unprecedented analysis of such transcripts. Here, we present an integrative approach to define a reference catalog of >8000 human lincRNAs. Our catalog unifies previously existing annotation sources with transcripts we assembled from RNA-seq data collected from ∼4 billion RNA-seq reads across 24 tissues and cell types. We characterize each lincRNA by a panorama of >30 properties, including sequence, structural, transcriptional, and orthology features. We…

• NS
  National Science Foundation
• HH
  Howard Hughes Medical Institute
• BW
  Burroughs Wellcome Fund
• DR
  Damon Runyon Cancer Research Foundation
• BI
  Broad Institute
• NI
  National Institutes of Health

  Award: 1DP2OD00667
• NH
  National Human Genome Research Institute