Pathogenesis of Mucormycosis
UCLA Medical Center · University of California, Los Angeles · +8 more institutions
Abstract
Mucormycosis is a life-threatening infection that occurs in patients who are immunocompromised because of diabetic ketoacidosis, neutropenia, organ transplantation, and/or increased serum levels of available iron. Because of the increasing prevalence of diabetes mellitus, cancer, and organ transplantation, the number of patients at risk for this deadly infection is increasing. Despite aggressive therapy, which includes disfiguring surgical debridement and frequently adjunctive toxic antifungal therapy, the overall mortality rate is high. New strategies to prevent and treat mucormycosis are urgently needed. Understanding the pathogenesis of mucormycosis and the host response to invading hyphae ultimately will…
Citation impact
- FWCI
- 13.03
- Percentile
- 100%
- References
- 71
Authors
4- ASAshraf S. IbrahimCorresponding
UCLA Medical Center, University of California, Los Angeles, Ronald Reagan UCLA Medical Center, The Lundquist Institute
- BSBrad Spellberg
Harbor–UCLA Medical Center
- TJThomas J. Walsh
New York Hospital Queens, NewYork–Presbyterian Hospital, Presbyterian Hospital, Cornell University
- DPDimitrios P. Kontoyiannis
The University of Texas MD Anderson Cancer Center
Topics & keywords
- Mucormycosis
- Medicine
- Diabetes mellitus
- Intensive care medicine
- Pathogenesis
- Transplantation
- Immunology
- Organ transplantation
- Good health and well-being