The Release 6 reference sequence of the Drosophila melanogaster genome

Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease. The initial reference genome sequence reported more than a decade ago had a profound impact on progress in Drosophila research, and improving the accuracy and completeness of this sequence continues to be important to further progress. We previously described improvement of the 117-Mb sequence in the euchromatic portion of the genome and 21 Mb in the heterochromatic portion, using a whole-genome shotgun assembly, BAC physical mapping, and clone-based finishing. Here, we report an improved reference sequence of the single-copy and middle-repetitive regions…

• UD
  U.S. Department of Energy

  Awards: -AC02-05CH11231, 05CH11231, 30295, AC02-05CH11231, DE-AC02, DE-AC02-05CH11231, DE-AC0376SF00098, DE-AC02-
• MD
  Ministerio de Economía y Competitividad

  Award: BFU2011-30295-C02-01
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico
• FC
  Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
• IP
  Istituto Pasteur-Fondazione Cenci Bolognetti
• NI
  National Institutes of Health

  Awards: R01 GM064590, DE-AC02-05CH11231