Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
Emory University · Virginia Commonwealth University · +7 more institutions
Abstract
Major depressive disorder is associated with considerable morbidity, disability, and risk for suicide. Treatments for depression most commonly include antidepressants, psychotherapy, or the combination. Little is known about predictors of treatment response for depression. In this study, 681 patients with chronic forms of major depression were treated with an antidepressant (nefazodone), Cognitive Behavioral Analysis System of Psychotherapy (CBASP), or the combination. Overall, the effects of the antidepressant alone and psychotherapy alone were equal and significantly less effective than combination treatment. Among those with a history of early childhood trauma (loss of parents at an early age, physical or…
Citation impact
- FWCI
- 26.68
- Percentile
- 100%
- References
- 21
Authors
14- CBCharles B. NemeroffCorresponding
Emory University, Virginia Commonwealth University, University of Washington, Western State Hospital
- CMChristine M. Heim
Emory University, Virginia Commonwealth University
- MEMichael E. Thase
Emory University, University of Washington, Western State Hospital
- DNDaniel N. Klein
Emory University
- AJA. John Rush
Emory University, Brown University, Stanford University
Topics & keywords
- Nefazodone
- Pharmacotherapy
- Depression (economics)
- Antidepressant
- Sexual abuse
- Psychiatry
- Interpersonal psychotherapy
- Chronic depression
- Good health and well-being