articleJNCI Journal of the National Cancer InstituteApr 29, 2015GREEN OA

US Assessment of HPV Types in Cancers: Implications for Current and 9-Valent HPV Vaccines

University of Southern California · University of Hawaii Cancer Center · +12 more institutions

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Abstract

Background

This study sought to determine the prevaccine type-specific prevalence of human papillomavirus (HPV)-associated cancers in the United States to evaluate the potential impact of the HPV types in the current and newly approved 9-valent HPV vaccines.

Methods

The Centers for Disease Control and Prevention partnered with seven US population-based cancer registries to obtain archival tissue for cancers diagnosed from 1993 to 2005. HPV testing was performed on 2670 case patients that were fairly representative of all participating cancer registry cases by age and sex. Demographic and clinical data were evaluated by anatomic site and HPV status. Current US cancer registry data and the detection of HPV types were used to estimate the number of cancers potentially preventable through vaccination.

Citation impact

759
total citations
FWCI
39.07
Percentile
100%
References
46
Citations per year

Authors

17

Topics & keywords

Keywords
  • Medicine
  • HPV vaccines
  • Cancer
  • Cervical cancer
  • Population
  • Oncology
  • Cancer registry
  • Vulvar cancer
UN Sustainable Development Goals
  • Good health and well-being
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Funding