Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study
UNC Lineberger Comprehensive Cancer Center · Roswell Park Comprehensive Cancer Center · +7 more institutions
Abstract
To determine population-based distributions and clinical associations for breast cancer subtypes. DESIGN, SETTING, AND PARTICIPANTS: Immunohistochemical surrogates for each subtype were applied to 496 incident cases of invasive breast cancer from the Carolina Breast Cancer Study (ascertained between May 1993 and December 1996), a population-based, case-control study that oversampled premenopausal and African American women. Subtype definitions were as follows: luminal A (ER+ and/or progesterone receptor positive [PR+], HER2-), luminal B (ER+ and/or PR+, HER2+), basal-like (ER-, PR-, HER2-, cytokeratin 5/6 positive, and/or HER1+), HER2+/ER- (ER-, PR-, and HER2+), and unclassified (negative for all 5 markers). MAIN OUTCOME MEASURES: We examined the prevalence of breast cancer subtypes within racial and menopausal subsets and determined their associations with tumor size, axillary nodal status, mitotic index, nuclear pleomorphism, combined grade, p53 mutation status, and breast cancer-specific survival.
The basal-like breast cancer subtype was more prevalent among premenopausal African American women (39%) compared with postmenopausal African American women (14%) and non-African American women (16%) of any age (P
Citation impact
- FWCI
- 60.77
- Percentile
- 100%
- References
- 53
Authors
17- LALisa A. CareyCorresponding
UNC Lineberger Comprehensive Cancer Center, Roswell Park Comprehensive Cancer Center, Conway School of Landscape Design, University of British Columbia, Public Health Department, Duke University Hospital, Centre for Advancing Health Outcomes, Duke Medical Center, University of North Carolina at Chapel Hill
- CMCharles M. Perou
Roswell Park Comprehensive Cancer Center, University of British Columbia, Duke University Hospital, Conway School of Landscape Design, Duke Medical Center, Public Health Department, Centre for Advancing Health Outcomes, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- CLChad Livasy
UNC Lineberger Comprehensive Cancer Center, Conway School of Landscape Design, Duke University Hospital, Duke Medical Center, Roswell Park Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Centre for Advancing Health Outcomes, Public Health Department, University of British Columbia
- LGLynn G. Dressler
University of British Columbia, Duke Medical Center, Public Health Department, UNC Lineberger Comprehensive Cancer Center, Conway School of Landscape Design, Roswell Park Comprehensive Cancer Center, Centre for Advancing Health Outcomes, Duke University Hospital, University of North Carolina at Chapel Hill
- DPDavid P. Cowan
Roswell Park Comprehensive Cancer Center, UNC Lineberger Comprehensive Cancer Center, Public Health Department, Duke University Hospital, Duke Medical Center, Conway School of Landscape Design, University of British Columbia, Centre for Advancing Health Outcomes, University of North Carolina at Chapel Hill
Topics & keywords
- Breast cancer
- Medicine
- Oncology
- Estrogen receptor
- Internal medicine
- Population
- Cancer
- Progesterone receptor
- Good health and well-being