Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy.
University of California, Los Angeles · University of California, Irvine · +1 more institution
Abstract
PURPOSE: Metastatic renal cell carcinoma (RCC) has a poor prognosis and an unpredictable course. To date, there are no molecular markers which can reliably predict RCC outcome. We investigated whether a novel kidney cancer marker, carbonic anhydrase IX (CAIX), is associated with progression and survival. EXPERIMENTAL DESIGN: Immunohistochemical analysis using a CAIX monoclonal antibody was performed on tissue microarrays constructed from paraffin-embedded specimens from patients (N = 321) treated by nephrectomy for clear cell RCC. CAIX staining was correlated with response to treatment, clinical factors, pathologic features, and survival. RESULTS: CAIX staining was present in 94% of clear cell RCCs. Survival…
Citation impact
- FWCI
- 12.49
- Percentile
- 100%
- References
- 46
Authors
15Topics & keywords
- Renal cell carcinoma
- Clear cell renal cell carcinoma
- Tissue microarray
- Medicine
- Hazard ratio
- Immunohistochemistry
- Targeted therapy
- Clear cell