Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
Chinese Academy of Sciences · Tsinghua University · +8 more institutions
Abstract
The genus Coronavirus contains about 25 species of coronaviruses (CoVs), which are important pathogens causing highly prevalent diseases and often severe or fatal in humans and animals. No licensed specific drugs are available to prevent their infection. Different host receptors for cellular entry, poorly conserved structural proteins (antigens), and the high mutation and recombination rates of CoVs pose a significant problem in the development of wide-spectrum anti-CoV drugs and vaccines. CoV main proteases (M(pro)s), which are key enzymes in viral gene expression and replication, were revealed to share a highly conservative substrate-recognition pocket by comparison of four crystal structures and a homology…
Citation impact
- FWCI
- 10.52
- Percentile
- 100%
- References
- 51
Authors
19- HYHaitao Yang
Chinese Academy of Sciences, Tsinghua University, Institute of Biophysics
- WXWeiqing Xie
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- XXXiaoyu Xue
Institute of Biophysics, Tsinghua University, Chinese Academy of Sciences
- KYKailin Yang
Institute of Biophysics, Chinese Academy of Sciences, Tsinghua University
- JMJing Ma
Institute of Biophysics, Tsinghua University, Chinese Academy of Sciences
Topics & keywords
- Proteases
- Biology
- Coronavirus
- Virology
- Enzyme
- Viral replication
- Virus
- Computational biology
- Good health and well-being