Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
Howard Hughes Medical Institute · Washington University in St. Louis · +2 more institutions
Abstract
Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid tissues, the transcription factors controlling their development and their relationship to other DC subsets remain unclear. Mice lacking the transcription factor Batf3 have a defect in the development of CD8alpha+ conventional DCs (cDCs) within lymphoid tissues. We demonstrate that Batf3(-/-) mice also lack CD103+CD11b- DCs in the lung, intestine, mesenteric lymph nodes (MLNs), dermis, and skin-draining lymph nodes. Notably, Batf3(-/-) mice displayed reduced priming of CD8 T cells after pulmonary Sendai virus infection, with increased pulmonary inflammation. In the MLNs and intestine, Batf3 deficiency resulted in the specific…
Citation impact
- FWCI
- 20.96
- Percentile
- 100%
- References
- 62
Authors
17- BTBrian T. Edelson
Howard Hughes Medical Institute, Washington University in St. Louis, Pulmonary and Critical Care Associates
- WKWumesh KC
Howard Hughes Medical Institute, Washington University in St. Louis, Pulmonary and Critical Care Associates
- RMRichard M. Juang
Howard Hughes Medical Institute, Washington University in St. Louis, Pulmonary and Critical Care Associates
- MKMasako Kohyama
Howard Hughes Medical Institute, Washington University in St. Louis, Pulmonary and Critical Care Associates
- LALoralyn A. Benoît
Howard Hughes Medical Institute, Washington University in St. Louis, Pulmonary and Critical Care Associates
Topics & keywords
- Immunology
- Mesenteric lymph nodes
- CD8
- Biology
- Cross-presentation
- Priming (agriculture)
- Immune system
- Inflammation
- Good health and well-being