The Universal Protein Resource (UniProt): an expanding universe of protein information

The Universal Protein Resource (UniProt) provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in protein bioinformatics. The UniProt Knowledgebase (UniProtKB), comprising the manually annotated UniProtKB/Swiss-Prot section and the automatically annotated UniProtKB/TrEMBL section, is the preeminent storehouse of protein annotation. The extensive cross-references, functional and feature annotations and literature-based evidence attribution enable scientists to analyse proteins and query across databases. The UniProt Reference Clusters (UniRef) speed similarity searches via sequence space compression by merging sequences that are…

• NS
  National Science Foundation

  Awards: 0205470, ITR-0205470, 0138188
• AG
  Australian Government
• EC
  European Commission
• NI
  National Institutes of Health
• NC
  National Cancer Institute
• NI
  National Institute of Allergy and Infectious Diseases