Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Xue, Jia; Schmidt, Susanne V.; Sander, Jil; Draffehn, Astrid M.; Krebs, Wolfgang; Quester, Inga; Nardo, Dominic De; Gohel, Trupti D.; Emde, Martina; Schmidleithner, Lisa; Ganesan, Hariharasudan; Niño‐Castro, Andrea; Mallmann, Michael R.; Labzin, Larisa I.; Theis, Heidi; Kraut, Michael; Beyer, Marc; Latz, Eicke; Freeman, Tom C.; Ulas, Thomas; Schultze, Joachim L.

doi:10.1016/j.immuni.2014.01.006

articleImmunityFeb 1, 2014HYBRID OA

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

JXJia Xue SVSusanne V. Schmidt JSJil Sander AMAstrid M. Draffehn WKWolfgang Krebs

University of Bonn · University of Massachusetts Chan Medical School · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Macrophage activation is associated with profound transcriptional reprogramming. Although much progress has been made in the understanding of macrophage activation, polarization, and function, the transcriptional programs regulating these processes remain poorly characterized. We stimulated human macrophages with diverse activation signals, acquiring a data set of 299 macrophage transcriptomes. Analysis of this data set revealed a spectrum of macrophage activation states extending the current M1 versus M2-polarization model. Network analyses identified central transcriptional regulators associated with all macrophage activation complemented by regulators related to stimulus-specific programs. Applying these…

Citation impact

2,163

total citations

FWCI: 70.51
Percentile: 100%
References: 53

Citations per year

Authors

21

Topics & keywords

Topics

Keywords

Macrophage polarization
Transcriptome
Macrophage
Biology
Cell biology
Alveolar macrophage
Reprogramming
COPD

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.