Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22
National Institute of Arthritis and Musculoskeletal and Skin Diseases · National Institutes of Health · +3 more institutions
Abstract
The interleukin (IL) 17 family of cytokines has emerged to be critical for host defense as well as the pathogenesis of autoimmune and autoinflammatory disorders, and serves to link adaptive and innate responses. Recent studies have identified a new subset of T cells that selectively produce IL-17 (Th17 cells; Bettelli, E., T. Korn, and V.K. Kuchroo. 2007. Curr. Opin. Immunol. 19:652-657; Kolls, J.K., and A. Linden. 2004. Immunity. 21:467-476), but the regulation of IL-17 production by innate immune cells is less well understood. We report that in vitro stimulation with IL-23 induced IL-17 production by recombination activating gene (Rag) 2(-/-) splenocytes but not Rag2(-/-) common gamma chain(-/-) splenocytes.…
Citation impact
- FWCI
- 16.95
- Percentile
- 100%
- References
- 31
Authors
8- HTHiroaki TakatoriCorresponding
National Institute of Arthritis and Musculoskeletal and Skin Diseases
- YKYuka Kanno
National Institute of Arthritis and Musculoskeletal and Skin Diseases
- WTWendy T. Watford
National Institute of Arthritis and Musculoskeletal and Skin Diseases
- CMCristina M. Tato
National Institute of Arthritis and Musculoskeletal and Skin Diseases
- GEGreta E. Weiss
National Institutes of Health, University of Pennsylvania
Topics & keywords
- Biology
- Innate lymphoid cell
- Recombination-activating gene
- Acquired immune system
- Cell biology
- Immunology
- Immune system
- CD11c