Abstract
Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators. Here, we report that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid (DHA) (C22:6) produce a novel family of bioactive 17R-hydroxy-containing di- and tri-hydroxy-docosanoids termed resolvins. Murine brain treated with aspirin produced endogenous 17R-hydroxydocosahexaenoic acid as did human microglial cells. Human COX-2 converted DHA to 13-hydroxy-DHA that switched with ASA to 17R-HDHA that also proved a major route in hypoxic endothelial cells. Human…
Citation impact
- FWCI
- 23.37
- Percentile
- 100%
- References
- 62
Authors
7- CNCharles N. SerhanCorresponding
Brigham and Women's Hospital, Harvard University
- SHSong Hong
Brigham and Women's Hospital, Harvard University
- KGKarsten Gronert
Brigham and Women's Hospital, Harvard University
- SPSean P. Colgan
Brigham and Women's Hospital, Harvard University
- PRPallavi R. Devchand
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Docosahexaenoic acid
- Endogeny
- Chemistry
- Lipid signaling
- Biochemistry
- Aspirin
- Cyclooxygenase
- Pharmacology