Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells
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Abstract
We analyzed the interaction between human peripheral blood natural killer (NK) cells and monocyte-derived immature dendritic cells (DC). Fresh NK cells were activated, as indicated by the induced expression of the CD69 antigen, and their cytolytic activity was strongly augmented by contact with lipopolysaccharide (LPS)-treated mature DC, or with immature DC in the presence of the maturation stimuli LPS, Mycobacterium tuberculosis or interferon (IFN)-alpha. Reciprocally, fresh NK cells cultured with immature DC in the presence of the maturation stimuli strongly enhanced DC maturation and interleukin (IL)-12 production. IL-2--activated NK cells directly induced maturation of DC and enhanced their ability to…
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Authors
6Topics & keywords
Topics
Keywords
- Interleukin 12
- Cell biology
- Biology
- Dendritic cell
- Interleukin 21
- Lymphokine-activated killer cell
- Immunology
- Janus kinase 3
UN Sustainable Development Goals
- Good health and well-being
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