articleThe Journal of Experimental MedicineOct 20, 2003BRONZE OA

Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential

LALouise A. KoopmanHDHernan D. KopcowBRBasya RybalovJEJonathan E. BoysonJSJordan S. Orange

Harvard University · Yale University · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Natural killer cells constitute 50-90% of lymphocytes in human uterine decidua in early pregnancy. Here, CD56(bright) uterine decidual NK (dNK) cells were compared with the CD56(bright) and CD56(dim) peripheral NK cell subsets by microarray analysis, with verification of results by flow cytometry and RT-PCR. Among the approximately 10,000 genes studied, 278 genes showed at least a threefold change with P

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Authors

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Topics & keywords

Topics
Keywords
  • Decidua
  • Biology
  • Flow cytometry
  • Natural killer cell
  • Receptor
  • Cell biology
  • Interleukin 21
  • Immunology
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