Voriconazole Therapeutic Drug Monitoring in Patients with Invasive Mycoses Improves Efficacy and Safety Outcomes
University Hospital of Lausanne · University of Lausanne
Indexed incrossrefpubmed
Abstract
Background
Voriconazole is the therapy of choice for aspergillosis and a new treatment option for candidiasis. Liver disease, age, genetic polymorphism of the cytochrome CYP2C19, and comedications influence voriconazole metabolism. Large variations in voriconazole pharmacokinetics may be associated with decreased efficacy or with toxicity.
Methods
This study was conducted to assess the utility of measuring voriconazole blood levels with individualized dose adjustments.
Citation impact
888
total citations
- FWCI
- 27.80
- Percentile
- 100%
- References
- 36
Citations per year
Authors
6Topics & keywords
Topics
Keywords
- Voriconazole
- Medicine
- Aspergillosis
- Internal medicine
- Gastroenterology
- Pharmacokinetics
- Toxicity
- Therapeutic drug monitoring
UN Sustainable Development Goals
- Good health and well-being
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