Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · Emory University · +2 more institutions
Abstract
Chronic viral infections often result in ineffective CD8 T-cell responses due to functional exhaustion or physical deletion of virus-specific T cells. However, how persisting virus impacts various CD8 T-cell effector functions and influences other aspects of CD8 T-cell dynamics, such as immunodominance and tissue distribution, remains largely unknown. Using different strains of lymphocytic choriomeningitis virus (LCMV), we compared responses to the same CD8 T-cell epitopes during acute or chronic infection. Persistent infection led to a disruption of the normal immunodominance hierarchy of CD8 T-cell responses seen following acute infection and dramatically altered the tissue distribution of LCMV-specific CD8…
Citation impact
- FWCI
- 15.94
- Percentile
- 100%
- References
- 93
Authors
5- EJE. John WherryCorresponding
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Emory University, Utrecht University, University of Washington
- JNJoseph N. Blattman
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Emory University, Utrecht University, University of Washington
- KMKaja Murali‐Krishna
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Emory University, Utrecht University, University of Washington
- RVRobbert van der Most
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Emory University, Utrecht University, University of Washington
- RARafi Ahmed
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Emory University, Utrecht University, University of Washington
Topics & keywords
- Biology
- Immunodominance
- Lymphocytic choriomeningitis
- Cytotoxic T cell
- Immunology
- CD8
- Epitope
- T cell
- Good health and well-being