Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
University College Dublin · Lund University · +3 more institutions
Abstract
UNLABELLED: Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall survival. We provide evidence that response to chemotherapy is in part regulated by these leukocytes; cytotoxic therapies induce mammary epithelial cells to produce monocyte/macrophage recruitment factors, including colony stimulating factor 1 (CSF1) and interleukin-34, which together enhance CSF1 receptor (CSF1R)-dependent macrophage infiltration. Blockade of macrophage recruitment with CSF1R-signaling antagonists, in combination with paclitaxel, improved…
Citation impact
- FWCI
- 46.47
- Percentile
- 100%
- References
- 71
Authors
15- DGDavid G. DeNardoCorresponding
University College Dublin, Lund University, Skåne University Hospital, Dublin City University, Plexxikon (United States)
- DJDonal J. Brennan
University College Dublin, Lund University, Skåne University Hospital, Dublin City University, Plexxikon (United States)
- ERElton Rexhepaj
University College Dublin, Lund University, Skåne University Hospital, Dublin City University, Plexxikon (United States)
- BRBrian Ruffell
University College Dublin, Lund University, Skåne University Hospital, Dublin City University, Plexxikon (United States)
- SLStephen L. Shiao
University College Dublin, Lund University, Skåne University Hospital, Dublin City University, Plexxikon (United States)
Topics & keywords
- Tumor microenvironment
- Cytotoxic T cell
- Immune system
- Cancer research
- Macrophage
- CD8
- Mammary tumor
- Biology
- Good health and well-being