mtDNA mutations increase tumorigenicity in prostate cancer
Emory Healthcare · Emory University · +3 more institutions
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Abstract
Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) gene, we found that 11-12% of all prostate cancer patients harbored COI mutations that altered conserved amino acids (mean conservation index=83%), whereas
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Authors
12- JAJohn A. Petros
Emory Healthcare, Emory University, Veterans Health Administration, Piedmont Cancer Institute, Winship Cancer Institute
- AKAmanda K. Baumann
Emory Healthcare, Emory University
- EREduardo Ruiz‐Pesini
Emory Healthcare, Emory University
- MBMahul B. Amin
Emory Healthcare, Emory University
- CSCarrie Sun
Emory Healthcare, Emory University, Piedmont Cancer Institute, Winship Cancer Institute
Topics & keywords
Topics
Keywords
- Heteroplasmy
- Biology
- Prostate cancer
- Mitochondrial DNA
- Cancer
- Mutation
- Genetics
- Cancer research
UN Sustainable Development Goals
- Life in Land
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