Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
Brigham and Women's Hospital · Harvard University · +3 more institutions
Abstract
The essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial effects in a range of human disorders associated with inflammation including cardiovascular disease. Resolvin E1 (RvE1), a new bioactive oxygenated product of EPA, was identified in human plasma and prepared by total organic synthesis. Results of bioaction and physical matching studies indicate that the complete structure of RvE1 is 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA. At nanomolar levels, RvE1 dramatically reduced dermal inflammation, peritonitis, dendritic cell (DC) migration, and interleukin (IL) 12 production. We screened receptors and identified one, denoted earlier as ChemR23, that mediates RvE1 signal…
Citation impact
- FWCI
- 31.02
- Percentile
- 100%
- References
- 30
Authors
9- MAMakoto AritaCorresponding
Brigham and Women's Hospital, Harvard University
- FBFrancesca Bianchini
Brigham and Women's Hospital, Harvard University
- JAJúlio Aliberti
National Institutes of Health, National Institute of Allergy and Infectious Diseases
- ASAlan Sher
National Institutes of Health, National Institute of Allergy and Infectious Diseases
- NCNan Chiang
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Eicosapentaenoic acid
- Lipid signaling
- Receptor
- Inflammation
- Mediator
- Interleukin 23
- Nuclear receptor
- Chemistry
- Life below water