Comparative lesion sequencing provides insights into tumor evolution
Howard Hughes Medical Institute · Johns Hopkins University · +7 more institutions
Abstract
We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes approximately 17 years for a large benign tumor to evolve into an advanced cancer but
Citation impact
- FWCI
- 18.83
- Percentile
- 100%
- References
- 62
Authors
14- SJSiân JonesCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Sidney Kimmel Cancer Center, Cancer Genetics (United States)
- WCWei-Dong Chen
Howard Hughes Medical Institute, University Hospitals of Cleveland
- GPGiovanni Parmigiani
Howard Hughes Medical Institute, Johns Hopkins University, Sidney Kimmel Cancer Center, Cancer Genetics (United States)
- FDFrank Diehl
Howard Hughes Medical Institute, Johns Hopkins University, Sidney Kimmel Cancer Center, Cancer Genetics (United States)
- NBNiko Beerenwinkel
Harvard University, Board of the Swiss Federal Institutes of Technology, ETH Zurich
Topics & keywords
- Carcinogenesis
- Colorectal cancer
- Metastasis
- Cancer research
- Biology
- Cancer
- Somatic evolution in cancer
- Cell
- Good health and well-being