Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
University of California, Los Angeles · University of Alabama at Birmingham · +2 more institutions
Abstract
For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific proinflammatory oxidized phospholipids that result from the oxidation of LDL phospholipids containing arachidonic acid and that are recognized by the innate immune system in animals and humans. These oxidized phospholipids are largely generated by potent oxidants produced by the lipoxygenase and myeloperoxidase pathways. The failure of antioxidant vitamins to influence clinical outcomes may have many explanations, including the inability of vitamin E to prevent the formation of these oxidized phospholipids and other…
Citation impact
- FWCI
- 18.72
- Percentile
- 100%
- References
- 127
Authors
13- MNMohamad NavabCorresponding
University of California, Los Angeles
- GMG. M. Ananthramaiah
University of Alabama at Birmingham, Center for Human Genetics, Institute of Human Genetics
- STSrinivasa T. Reddy
University of California, Los Angeles
- BJBrian J. Van Lenten
University of California, Los Angeles
- BJBenjamin J. Ansell
University of California, Los Angeles
Topics & keywords
- Myeloperoxidase
- Arachidonic acid
- Cholesterol
- Lipoxygenase
- Biochemistry
- Chemistry
- Inflammation
- Proinflammatory cytokine