Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Centre for Inflammation Research · Medical Research Council · +4 more institutions
Abstract
Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl(4)-induced model of reversible hepatic fibrosis to identify and characterize the macrophage phenotype responsible for tissue remodeling: the hitherto elusive restorative macrophage. This CD11B(hi) F4/80(int) Ly-6C(lo) macrophage subset was most abundant in livers during maximal fibrosis resolution and represented the principle matrix metalloproteinase (MMP) -expressing subset. Depletion of this population in CD11B promoter-diphtheria toxin receptor (CD11B-DTR) transgenic mice caused a failure of scar remodeling. Adoptive transfer and in situ labeling experiments showed that these…
Citation impact
- FWCI
- 21.64
- Percentile
- 100%
- References
- 62
Authors
17- PRPrakash Ramachandran
Centre for Inflammation Research, Medical Research Council, University of Edinburgh
- APAntonella Pellicoro
Centre for Inflammation Research, Medical Research Council, University of Edinburgh
- MAMadeleine A. Vernon
Centre for Inflammation Research, Medical Research Council, University of Edinburgh
- LBLuke Boulter
Centre for Inflammation Research, Medical Research Council, University of Edinburgh
- RLRebecca L. Aucott
Centre for Inflammation Research, Medical Research Council, University of Edinburgh
Topics & keywords
- Biology
- Fibrosis
- Integrin alpha M
- Inflammation
- Population
- Macrophage
- CD11c
- Cell biology