articleProceedings of the National Academy of SciencesMar 5, 2012BRONZE OA

Salience network integrity predicts default mode network function after traumatic brain injury

VBValérie BonnelleTHTimothy HamRLRobert LeechKMKirsi M. KinnunenMAMitul A. Mehta

Cognitive Neuroimaging Lab · Imperial College London · +5 more institutions

PubMed
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Abstract

Efficient behavior involves the coordinated activity of large-scale brain networks, but the way in which these networks interact is uncertain. One theory is that the salience network (SN)--which includes the anterior cingulate cortex, presupplementary motor area, and anterior insulae--regulates dynamic changes in other networks. If this is the case, then damage to the structural connectivity of the SN should disrupt the regulation of associated networks. To investigate this hypothesis, we studied a group of 57 patients with cognitive impairments following traumatic brain injury (TBI) and 25 control subjects using the stop-signal task. The pattern of brain activity associated with stop-signal task performance…

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Topics & keywords

Topics
Keywords
  • Neuroscience
  • Default mode network
  • Anterior cingulate cortex
  • Task-positive network
  • White matter
  • Precuneus
  • Psychology
  • Diffusion MRI
UN Sustainable Development Goals
  • Good health and well-being
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