Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis
Human Genome Sciences (United States) · Wellcome Centre for Molecular Parasitology · +13 more institutions
Abstract
We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common…
Citation impact
- FWCI
- 42.95
- Percentile
- 100%
- References
- 37
Authors
65- JMJane M. CarltonCorresponding
Human Genome Sciences (United States), Wellcome Centre for Molecular Parasitology, Center for Genomic Science, University of Maryland, College Park, Newcastle University, Technical University of Denmark
- RPRobert P. Hirt
Human Genome Sciences (United States), Wellcome Centre for Molecular Parasitology, Center for Genomic Science, University of Maryland, College Park, Newcastle University, Technical University of Denmark
- JCJoana C. Silva
Human Genome Sciences (United States), Wellcome Centre for Molecular Parasitology, Center for Genomic Science, University of Maryland, College Park, Newcastle University, Technical University of Denmark
- ALArthur L. Delcher
Human Genome Sciences (United States), Wellcome Centre for Molecular Parasitology, Center for Genomic Science, University of Maryland, College Park, Newcastle University, Technical University of Denmark
- MCMichael C. Schatz
Human Genome Sciences (United States), Wellcome Centre for Molecular Parasitology, Center for Genomic Science, University of Maryland, College Park, Newcastle University, Technical University of Denmark
Topics & keywords
- Biology
- Genome
- Trichomonas vaginalis
- Genetics
- Trichomonas
- Gene
- Transposable element
- Whole genome sequencing