T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity
Houston Methodist · Baylor College of Medicine · +2 more institutions
Abstract
BACKGROUND: Obesity is associated with chronic inflammation, which includes increased macrophage accumulation in adipose tissue (AT) and upregulation of chemokines and cytokines. T cells also play important roles in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity. METHODS AND RESULTS: Flow cytometric analysis showed higher numbers of T cells and macrophages in AT of diet-induced obese insulin-resistant male mice than in lean mice and obese females (P
Citation impact
- FWCI
- 27.49
- Percentile
- 100%
- References
- 31
Authors
11- HWHuaizhu WuCorresponding
Houston Methodist, Baylor College of Medicine, National Institute of Nutrition, Endocyte (United States)
- SGSudip Ghosh
Houston Methodist, Baylor College of Medicine, National Institute of Nutrition, Endocyte (United States)
- XDXiaoyuan Dai Perrard
Houston Methodist, Baylor College of Medicine, National Institute of Nutrition, Endocyte (United States)
- LFLili Feng
Houston Methodist, Baylor College of Medicine, National Institute of Nutrition, Endocyte (United States)
- GGGabriela García
Houston Methodist, Baylor College of Medicine, National Institute of Nutrition, Endocyte (United States)
Topics & keywords
- Adipose tissue
- Downregulation and upregulation
- Medicine
- Cell
- Cell biology
- Adipose tissue macrophages
- Obesity
- Endocrinology
- Good health and well-being