MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
Massachusetts General Hospital · Harvard University · +8 more institutions
Abstract
Substantial data indicate that microRNA 21 (miR-21) is significantly elevated in glioblastoma (GBM) and in many other tumors of various origins. This microRNA has been implicated in various aspects of carcinogenesis, including cellular proliferation, apoptosis, and migration. We demonstrate that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs). Specific inhibition of miR-21 with antisense oligonucleotides leads to elevated levels of RECK and TIMP3 and therefore reduces MMP activities in vitro and in a human model of gliomas in nude mice.…
Citation impact
- FWCI
- 24.34
- Percentile
- 100%
- References
- 62
Authors
7- GGGalina Gabriely
Massachusetts General Hospital, Harvard University, Brigham and Women's Hospital
- TWThomas Würdinger
Amsterdam UMC Location VUmc, Cancer Center Amsterdam, Dana-Farber Brigham Cancer Center, Gordon Center for Medical Imaging, Center for Neuro-Oncology, Harvard University, Massachusetts General Hospital
- SKSantosh Kesari
Center for Neuro-Oncology, Massachusetts General Hospital, Brigham and Women's Hospital, Regulus Therapeutics (United States), Dana-Farber Brigham Cancer Center, Harvard University
- CEChristine Esau
Rosetta Stone (United States), Regulus Therapeutics (United States)
- JBJulja Burchard
Brigham and Women's Hospital, Harvard University, Rosetta Stone (United States)
Topics & keywords
- Biology
- Downregulation and upregulation
- Glioma
- Cancer research
- Matrix metalloproteinase
- microRNA
- Oncomir
- Carcinogenesis
- Good health and well-being