Role of Microglia in Central Nervous System Infections
University of Minnesota · Orthopaedic Research Foundation
Abstract
The nature of microglia fascinated many prominent researchers in the 19th and early 20th centuries, and in a classic treatise in 1932, Pio del Rio-Hortega formulated a number of concepts regarding the function of these resident macrophages of the brain parenchyma that remain relevant to this day. However, a renaissance of interest in microglia occurred toward the end of the 20th century, fueled by the recognition of their role in neuropathogenesis of infectious agents, such as human immunodeficiency virus type 1, and by what appears to be their participation in other neurodegenerative and neuroinflammatory disorders. During the same period, insights into the physiological and pathological properties of…
Citation impact
- FWCI
- 15.88
- Percentile
- 100%
- References
- 391
Authors
7- RBR. Bryan RockCorresponding
University of Minnesota, Orthopaedic Research Foundation
- GGGenya Gekker
University of Minnesota, Orthopaedic Research Foundation
- SHShuxian Hu
University of Minnesota, Orthopaedic Research Foundation
- WSWen S. Sheng
University of Minnesota, Orthopaedic Research Foundation
- MCMaxim C.‐J. Cheeran
University of Minnesota, Orthopaedic Research Foundation
Topics & keywords
- Microglia
- Central nervous system
- Neuroscience
- Neuroprotection
- Biology
- Neuroinflammation
- Immunology
- Chemokine
- Good health and well-being