The Role of Metallothionein in Oxidative Stress
Central European Institute of Technology · Brno University of Technology · +4 more institutions
Abstract
Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous…
Citation impact
- FWCI
- 26.15
- Percentile
- 100%
- References
- 187
Authors
9- BRBranislav Ruttkay-Nedecký
Central European Institute of Technology, Brno University of Technology
- LNLukáš Nejdl
Mendel University in Brno
- JGJaromír Gumulec
Central European Institute of Technology, Masaryk University, Brno University of Technology
- OZOndřej Zítka
Central European Institute of Technology, Mendel University in Brno, Brno University of Technology
- MMMichal Masařík
Central European Institute of Technology, Masaryk University, Brno University of Technology
Topics & keywords
- Metallothionein
- Oxidative stress
- Radical
- Chemistry
- Electrophile
- Zinc
- Cysteine
- Intracellular