Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors

Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of…

• AF
  Arthritis Foundation

  Award: K08 AI01521
• NI
  National Institutes of Health

  Awards: AI50864, K08 AI01521
• NH
  National Heart, Lung, and Blood Institute